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While advances in bioinformatics and nanoformulations are enhancing their pharmacokinetic profiles and clinical applicability, challenges such as standardization, dosage optimization, and translational validation hinder their widespread clinical adoption

For example, one clinical study found that pre-injecting 0.9% benzyl alcohol solution (bacteriostatic saline) greatly reduced propofol injection pain compared to placebo

Because of how quickly they break down and are cleared from the bloodstream, most had to be injected instead of taken orally, he said

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