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An alternative and powerful strategy for treatment intensification in T2DM is combination therapy with basal insulin and GLP-1 RA to harness the different mechanisms and target the various tissues of insulin and GLP-1 RA action [3, 4]
Shay, Marc S
Why Demand Keeps Exploding Semaglutide based treatments have gained popularity because clinical studies show meaningful weight reduction alongside metabolic health improvements
Reviews caution that it may intensify hypotensive responses or alter drug absorption, underscoring the need for comprehensive medication reconciliation
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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