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AbbVie has been successfully renewing its immunology franchise through strong growth of Skyrizi (risankizumab) and Rinvoq (upadacitinib)

Theophylline and theobromine are methylxanthine compounds that may dilate blood vessels, reducing gut inflammation and supporting elimination

The most commonly reported side effects include: Nausea Diarrhoea Vomiting Mild stomach discomfort Constipation In TRIUMPH-1, treatment discontinuation due to adverse events rose with dose: approximately 4.1% at 4 mg, 6.9% at 9 mg, and 11.3% at 12 mg , compared with 4.9% in the placebo group

Loss of the normal lobular architecture with irregular growth pattern