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When NNMT activity is high, less nicotinamide enters this pathway and intracellular NAD+ levels fall
Drop back to the last tolerated dose and stay there for 6-8 weeks before attempting escalation again
As B12 is essential for the production of red blood cells and proper nervous system function, its deficiency can disrupt these processes and lead to symptoms like gastrointestinal discomfort and poor appetite, which may contribute to unintended weight loss
Regular B12 supplementation supports red blood cell production, nerve health, cognitive function, and energy metabolism
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