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But this is experimental territory with zero clinical data supporting the approach
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In summary, GLP-1RAs have the potential to inhibit neuroinflammation and promote nerve regeneration through the "Tregs-microglia-neuron/NPCs" axis: (1) GLP-1RAs directly and indirectly inhibit the activation of microglia, promote their M2 polarization, and secrete cytokines such as IL-4, IL-10, TGF - , IL-2 to exert anti-inflammatory effects (100)
The SAFE Drugs Act, introduced in December 2025, would expand the FDA's power over compounded and unregulated GLP-1 products and the telehealth companies that prescribe them (Dykema analysis)
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