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Within a substrate-aware framework, clinical surveillance may therefore include periodic assessment of (i) lean mass trajectory, (ii) micronutrient statusparticularly nutrients supporting enzymatic throughput and redox cyclingand (iii) fat-soluble vitamin indices as indirect indicators of bile-dependent absorption integrity

In 1958, Fritz discovered that L-carnitine could increase the rate of fat metabolism in mitochondria, clarified its fundamental role in fat oxidation, and revealed it to be an essential nutrient for the human body

10.1158/0008-5472.CAN-04-4267 51 HussainH.AliI.WangD.HakkimF

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