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Key findings from SURMOUNT-1 include a mean weight loss of 15.0% at the 5mg dose, 19.5% at the 10mg dose, and 20.9% at the 15mg dose over 72 weeks
Others prefer morning injections so the nausea peaks during the day when they can manage it actively
This dual mechanism is what makes it more effective than single-agonist medications, but it also means the body needs adequate time to adjust to each dose increase
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