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Finally, there is some clinical evidence suggesting that high doses of carnitine may lower the seizure threshold in susceptible individuals, making medical supervision essential for those with a history of seizure disorders

Lawsuits allege that some doctors encouraged off-label use of these medications for weight loss patients without providing adequate warnings about possible side effects like delayed gastric emptying, severe gastroparesis, and sudden vision loss

Fourth, small-molecule oral drugs may offer manufacturing and scalability advantages versus peptide-based injectables

"We're not sure why, but it does tend to get better with time," Corrado says