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Data availability The protein structure from accession codes 1e17 (FOXO4 FHD) was obtained from the PDB at All other data are available from the corresponding author upon reasonable request

Sikorska et al., 2008), we raise the following questions: (i) does the observed methylation of Sox2 in astrocytes also occur in aged stem cells and would it decrease their ability to differentiate and give rise to new neurons

Systemic effects documented in animal studies -- lung tissue protection, neurological effects, joint healing -- are not achievable through topical application