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Translation is constrained by uncertainty around optimal molecule choice, CNS penetrance, tolerability, adherence, and heterogeneity of response

The L-cells in the intestinal epithelium express various nutrient-sensing receptors: Dietary fats are particularly potent GLP-1 secretagogues, activating free fatty acid receptors (such as GPR40 and GPR120) on L-cells Proteins and amino acids stimulate GLP-1 through peptide-sensing mechanisms and calcium-sensing receptors Carbohydrates trigger release via glucose transporters and sweet taste receptors expressed on enteroendocrine cells Dietary fibre , particularly soluble fibre, promotes GLP-1 secretion through fermentation products (short-chain fatty acids) produced by gut microbiota The rate and site of nutrient delivery also influences GLP-1 response

Statins are still the best-studied drug class for primary prevention, while newer LDL-lowering approaches are promising but not yet a reason to overhaul routine care on their own.What is already establishedThe CDC advises healthy eating, physical activity, not smoking, and weight management as core prevention steps

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