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Endothelial cells are crucial for regulating microcirculation and maintaining tissue and organ barriers and are widely recognized as target cells for TMAO
This pattern of regulation suggests a shift toward more favourable nitric oxide (NO) production, as eNOS and nNOS are typically involved in the generation of low, physiological levels of NO, which play key roles in maintaining vascular tone, blood flow, and neuronal function [68, 69]
The GCLC floxed X CaMKII-Cre mouse was named here as GCLC-KO for the sake of convenience
doi:10.1017/S1368980016002603
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