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In CD8+ T cells, an MFN2-SERCA2 axis supports ER-mitochondria calcium homeostasis and mitochondrial metabolic competence, and disruption of this module compromises effector function and antitumor immunity, while reinforcement improves therapeutic efficacy, positioning ER-mitochondria interfaces as regulatory hubs that connect chronic stimulation to durable dysfunction (50)
2007 Jul;30(7):834-9
Slower-acting peptides (GHK-Cu, Epithalon) hit their stride
BPC-157 is a synthetic 15-residue peptide with the sequence GEPPPGKPADDAGLV
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