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Sorafenib causes the production of P62, which inhibits NRF2 degradation and promotes the inactivation of KEAP1, followed by the activation of heme oxygenase-1 (HO-1), quinone oxidoreductase-1, and ferritin heavy chain-1, which enhances NRF2 nuclear localization

Moreover, null or inconsistent findings in some mechanistic trials, including absent changes in certain satiety hormones or mixed reward-response patterns, underscore the complexity of these pathways

And, carefully monitor your blood glucose levels regularly when taking this medication