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Tumor cells resist the toxicity of chemotherapy drugs by enhancing GSH synthesis or reducing its consumption, leading to chemotherapy resistance (16)
Extensively studied in research models for its role in metabolic signaling, body composition, and endocrine system regulation
Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP trial)
Evidence boundary The largest Phase 2b trial used oral dosing for 24 weeks and did not show statistically significant weight loss versus placebo
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