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During this period, brain growth is rapid, increasing the susceptibility to influences from the environment.27 This is also the period when most of the myelination of the brain occurs.9 In infants, moderate and severe vitamin B 12 deficiency has been associated with demyelination and brain atrophy.28 29 Little is known about the consequences of maternal vitamin B 12 deficiency for early brain myelination, neurodevelopment and cognitive function

It shows a predilection for the craniofacial sites and the most common site affected is anterior maxilla

When they are stopped, production returns to its baseline rather than crashing

The inhibition of this pathway by GSK0600 underscored its essential role in mediating the effects of C3G