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GSTM2 modulates size and number of LDs in HepG2 cells To further investigate the potential regulatory mechanism, we generated a GSTM2 -knockdown stable cell line (shGSTM2-HepG2) that expressed less GSTM2 mRNA and protein than control cells (shNC-HepG2) (Fig

The body synthesizes glutathione through the -glutamyl cycle , which involves three key enzymatic reactions: 1

Studies demonstrate that the ability of animal species to protect mitochondrial DNA through glutathione-dependent mechanisms is directly proportional to longevity across species