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Summary: True vitamin B12 overdose is exceptionally rare because it is water-soluble and excess amounts are excreted through urine rather than accumulating in body tissues

After comparison of the redox titrations of ROXY9 and GRXC2 with either GSH/GSSG or DTT/dithiane, we had concluded that GRXC2, but not ROXY9, accepts low amounts of GSSG as a substrate for an oxidative half-reaction because of its favourable scaffold site leading to glutathionylation at Cys A

That is the mechanistic case for the blend in one paragraph and it is exactly why the two are described as complementary rather than redundant

References Beird HC, Bielack SS, Flanagan AM, et al