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Exclusion criteria: type 1 diabetes, insulin therapy, renal dysfunction (eGFR less than 30 ml/min), severe liver dysfunction or cirrhosis, usage of -glucosidase inhibitors such as acarbose, oral or injectable corticosteroids usage, pregnancy, lactation or nursing, or wishing to conceive

Documented laboratory research contexts include: Analytical investigation of NNMT-related metabolic and methylation pathways in experimental model systems Evaluation of enzymeinhibitor interactions involving nicotinamide metabolism under controlled laboratory conditions Molecular pathway mapping associated with NAD-related metabolic signaling in research environments Analytical reference use in chromatographic method development and compound characterization Stability assessment and purity verification within non-clinical laboratory workflows All referenced applications are strictly confined to controlled laboratory research and non-clinical experimental use