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Long-Term Weight Management: Semaglutide and tirzepatide can be effective tools for long-term weight management when combined with lifestyle changes

Additionally, the initial rapid weight loss phase is partly driven by reduced calorie intake and partly by metabolic changes

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This specific ICV dose was empirically derived from a systemic equivalent of 10 mg/kg, adjusted based on the approximate brain-to-body weight ratio of a mouse, approximately 1:100