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The percentage of patients diagnosed with thyroid cancer was 0.23% in the DPP4i group, 0.17% in the GLP-1RA group, 0.17% in the SGLT2i group, and 0.20% in the SU group

DPP-IV is an enzyme responsible for the degradation of incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP)

GLP-1 receptor agonists in the treatment of type 2 diabetesstate-of-the-art

Lysine 17 (K17) with Glu1.33b: Before branching out into the complex lipidation spacer, the primary amine of the Lys17 residue on the peptide engages in a highly specific salt bridge with the negatively charged glutamic acid located at position 1.33b of the GLP-1 receptor