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Researchers confirmed it was GLP-1 receptor-dependent by showing that the effect reversed when they blocked the receptor with a specific antagonist

Zhang Q, Chibalina MV, Bengtsson M et al (2014) Na+ current properties in islet alpha- and beta-cells reflect cell-specific Scn3a and Scn9a expression

While these medications can be incredibly supportive tools for weight loss, its not uncommon to experience digestive woes (especially in the beginning)