A 2003 double-blind placebo-controlled trial by Humbert and colleagues in Experimental Dermatology applied 5% topical ascorbic acid cream versus vehicle to the low-neck and arms of healthy women with photoaged skin for 6 months, with assessments at baseline, 3 months, and 6 months, and found that active treatment improved skin relief and silicone-replica topography and produced favorable changes on end-of-study immunohistochemistry and electron microscopy of dermal biopsies biopsy-level evidence of structural remodeling, not merely surface appearance
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Numerous EDCs have been already identified as thyroid disruptors and mechanisms of their harmful effects haveat least partiallybeen known, comprising effects at the level of thyroid hormone synthesis, release, transport, metabolism, clearance, and hormone interactions with its receptor in target tissues [9, 24,25,26,27]
