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The American College of Physicians (ACP) also recommends adding a GLP-1 agonist to metformin in patients with inadequate glycemic control to reduce morbidity and mortality

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Anthraquinones can injure and kill epithelial cellsthe cells that make up the colon's lining

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If several doses in a row are missed (specifically a break of 14 days or more), you will lose your tolerance to the medication and must restart from the lowest introductory dose

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