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This third mechanism increases energy expenditure, which may explain why retatrutide shows greater weight loss in early clinical data (~2428% vs ~1621% for tirzepatide)

Some studies show that it is successful in healing lesions in the gut system, such as the stomach and small intestines

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This is consistent with GHK-Cus known role in upregulating collagen synthesis in dermal fibroblasts, a mechanism confirmed in a comprehensive review in Biomolecules documenting GHK-Cus influence across more than 4,000 human genes involved in tissue remodeling and repair