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Phase 3 TRIUMPH Program (Ongoing) First successful readout: TRIUMPH-4 (obesity/overweight + knee osteoarthritis, no diabetes

GLP-1 RAs have been found to improve body weight, blood pressure (BP), lipid profile levels, and myocardial infarction (MI) outcomes even in nondiabetic patients without increasing the risk of hypoglycemic events ( Our narrative review aimed to discuss the CV benefits of GLP-1 RAs in terms of controlling CV risk factors and improving HF outcomes, and the CV perspectives related to their use in clinical practice

This search is based on observations that the effects of oral glucose can't always be fully explained by GLP-1 and GIP alone, suggesting another player might be on the field

The goal is not just weight loss, but preserving muscle, strength, hydration, and overall health during treatment