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10.1007/s11095-020-02801-3 16 NohY.KimD
Use raw heart-rate change rather than placebo-subtracted when assessing drug-attributable load: the placebo arm shows real cardiovascular adaptation from weight loss and lifestyle counseling, so subtraction over-corrects
Progress should be assessed through body composition analysis, circumference measurements, and photos rather than scale weight alone, as muscle preservation can mask fat loss on the scale
However, before you do so, there are some important factors you must consider
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