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Fertility of male or female rats was unaffected by metformin when administered at doses as high as 600 mg/kg/day, which is approximately 3-times the maximum recommended human dose based on body surface area comparisons

Glucagon-like peptide-2 inhibits antral emptying in man, but is not as potent as glucagon-like peptide-1

Weekly semaglutide injections are generally considered for patients with a BMI of 30 kg/m or higher, or for those with a BMI of at least 27 kg/m who also have a weight-related medical problem

Injecting outside approved sites or into areas with poor subcutaneous tissue, active skin conditions, or scar tissue may compromise medication delivery and increase infection risk