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Uchida H, Nakajima Y, Ohtake K, et al
PMCID: PMC4701895
Applying patches to skin that is damp, oily, or covered with lotion creates a barrier that prevents proper contact and may lead to premature detachment or inconsistent medication delivery
214,215,216,217 Additionally, sensory neurons in the dorsal root ganglia (DRG) exhibit altered phenotypes, such as reduced neurofilament synthesis, endoplasmic reticulum stress, and changes in key plasticity molecules, such as growth-associated protein 43 (GAP43) and heat shock proteins, leading to mitochondrial dysfunction and loss of peripheral nerve function
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