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Researchers who are sensitive to gastrointestinal side effects or who have experienced significant issues with semaglutide constipation or tirzepatide GI issues may find cagrilintide monotherapy more tolerable, even at the cost of somewhat lower weight loss
Preliminary research indicates potential influences on visceral fat metabolism, protein turnover, and structural tissue dynamics
Many patients take their injection before bed to sleep through initial nausea
In animal studies, administration of dexamethasone caused a reduction of GLP-1 secretion from the intestinal L cells [80] and also decreased the circulating levels of this peptide, which led to glucose intolerance and peripheral insulin resistance in rats [81]
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