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Although the direct inhibition of DPP-4 activity does not seem to regulate bone remodeling, the impact of DPP-4 on bone metabolism is indirect, involving the modulation of DPP-4 substrates and inflammation within the bone microenvironment

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Ciertos alimentos se asocian a una mayor liberacin natural de GLP-1, entre ellos: Alimentos ricos en protenas, como huevos, pescado y legumbres Alimentos ricos en fibra, como verduras, cereales integrales y legumbres Alimentos fermentados que favorecen la salud intestinal, como el yogur y el kfir (4,5) En general, una dieta que favorezca la salud intestinal parece favorecer una mejor actividad del GLP-1, que es en parte la razn por la que la investigacin sobre el microbioma intestinal ha cobrado relevancia en este mbito

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GPX4 is a crucial selenoprotein that converts toxic lipid hydroperoxides (L-OOH) on the cytoplasmic membrane to non-toxic lipid alcohol (L-OH) by utilizing GSH, thus preventing the accumulation of lipid peroxidation to protect cells from ferroptosis (191)

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