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doi: 10.3389/fphar.2019.00476 Received 16 January 2019 Accepted 16 April 2019 Published 16 May 2019 Volume 10 - 2019 Edited by Nabil Eid, Osaka Medical College, Japan Reviewed by Jae-Sung Kim, Saint Louis University, United States

The treatment difference was 0.21% with confidence intervals (0.080.34%) extending beyond 0.3% and so non-inferiority was not demonstrated, i.e