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Analogs of GLP-1 have emerged as attractive diabetes treatments because of their favorable safety and efficacy profiles in lowering blood glucose levels through pancreatic betacellmediated glucosedependent insulin secretion and suppression of glucagon release
These drugs, originally approved for type 2 diabetes, lower A1c, slow digestion to increase satiety, increase fat utilization, and have led to dramatic weight loss results of around 12%17% of body weight after 48 weeks of use
Top-line outcomes: STEP 4 maintenance data is particularly relevant for researchers modelling discontinuation effects: participants who stopped Semaglutide regained approximately two-thirds of lost weight within 1 year, while those continuing maintained their loss, supporting the hypothesis that chronic GLP-1R engagement is required for sustained metabolic effects
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