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The FDA label also includes warnings about fluid retention (which can cause edema, joint pain, and carpal tunnel syndrome), glucose intolerance or diabetes, elevated IGF-1 levels that require monitoring, increased risk of neoplasms or abnormal cell growth (because Tesamorelin stimulates the release of growth hormone, it is contraindicated in patients with active malignancy), hypersensitivity reactions, and increased mortality risk in critically ill patients (a class-effect warning related to growth hormone-releasing products generally)

Al-Malki AL, Sayed AAR

doi: 10.1016/j.freeradbiomed.2020.10.002 128 JarrottB.HeadR.PringleK