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Tirzepatide is a dual GLP-1/GIP receptor agonist, which means it activates two important hormonesglucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

This means it mimics a hormone in your body called GLP-1, which: Slows down digestion so you feel full longer Signals your brain that you're satisfied after eating Helps your pancreas release insulin when your blood sugar rises Reduces your liver's glucose production These effects help reduce appetite and improve blood sugar control, leading to weight loss for many people

Interactions of glucagon-like peptide-1 (GLP-1) with the bloodbrain barrier

Notably, the glucoregulatory and anorectic activities of GIP and GLP-1 have supported development of incretin-based therapies for the treatment of type 2 diabetes and obesity