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Because beta-cell function is essential for proper intrinsic insulin response to increased BG levels, therapies that have the potential to improve cell function may help slow the progression of insulin resistance
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This was supported by a recent metanalysis in which, twenty- two randomized controlled trials involving 61,412 patients who were either T2DM patients with or without cardiovascular disease or patients with cardiovascular disease alone, were included in the meta-analysis, and results have shown the diastolic function according to echocardiography was significantly improved by GLP-1R agonists [88]
Even with consistent effort, some individuals struggle to shed weight due to underlying metabolic factors that make fat loss more challenging
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