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In ALS patients, no significant differences in serum IL-2 levels versus control subjects were reported [82, 83] suggesting that this cytokine might have a limited input in the immune system response, at least in the early stage of disease (14.3 9.34 months disease duration in [83])

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In a frequently cited 1999 rat wound study in the Journal of Investigative Dermatology, topical Thymosin Beta-4 was associated with a 42% increase in reepithelialization at four days and as much as 61% at seven days compared with saline controls, alongside increased angiogenesis