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The benefit of GLP-1 RAs exceeded the harms for weight loss in the first 2 years of treatment, yet the net benefit was dependent on individual treatment goals (10% or 5% weight loss) and willingness to accept harms in pursuit of weight loss
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A better understanding of these adaptive mechanisms of gastric mucosa after RYGB and VSG and their exploitation will help in the development of new approaches to bariatric surgeries and possibly allow to replace them with less invasive and gastric-targeted endocrine therapies for the treatment of obesity-related diabetes
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