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Common sedatives include: Benzodiazepines like Valium (diazepam) and Klonopin (clonazepam) Kava L-tryptophan Melatonin Opioid medications like Roxicodone or Xtampza ER (oxycodone) Sleeping medications like Ambien (zolpidem) Taking ashwagandha with sedatives or other sleep medications may lead to excessive drowsiness, sleepiness, or trouble breathing