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Data show that up to two-thirds of patients with HFpEF have CAD or coronary microvascular dysfunction including ischaemia, which leads to disruption of LV diastolic and systolic function, development of fibrosis, increased myocardial stiffness and cardiac remodelling
Jacobsen L, Hindsberger C, Robson R, et al
In animal models, visible effects typically appear after 4-6 weeks of consistent dosing, with long-term treatment producing weight loss and increased lipolytic sensitivity
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