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doi: 10.1053/j.gastro.2004.04.063 35 PocaiA
Prediabetes: a high-risk state for diabetes development
Many cardiovascular risk factors such as diabetes mellitus, hypertension and hyperlipidemia are demonstrated to stimulate the interaction of Cav-1 and eNOS, reduce nitric oxide production resulting in endothelial dysfunction and subsequently the formation of atherosclerotic lesion 41,42,43
Though mutants lacked GSH (a strong antioxidant), they were less susceptible to modest oxidative stress by hydrogen peroxide, and we attributed these changes to extracellular acidification and a low extracellular pH
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