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In a breakthrough study published in Nature Cell Biology, scientists at Rockefeller University have unveiled a pivotal mechanism by which cells maintain the redox homeostasis of the endoplasmic reticulum (ER)a cellular organelle integral to protein synthesis and folding

In human somatic cells, telomerase is normally silenced after embryonic development, meaning telomeres shorten with each cell division until reaching a critical length that triggers replicative senescence or apoptosis

This is because one of its key building blocks is the sulfur-containing amino acid cysteine

In two recent studies, knock-in mice carrying dominant-negative Nr1h3 mutations (W441F and W441R) exhibited more severe liver injury than Nr1h3 -knockout mice following a MASH-inducing diet 32,52