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The most common experiences include slight nausea (particularly with first doses), minor fatigue or drowsiness, temporary dizziness, injection site reactions like mild redness or itching, and sleep disturbances (usually with evening dosing)
When treated with 5FU, cancer cells specifically increase mitochondrial content to buffer nucleotide stress, whereas stromal cells do not, meaning that cancer cells become intrinsically more dependent on mitochondrial metabolism
Am J Med 2001;110:616-22
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