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Notably, Gpx4 +/IEC mice were susceptible to colonic inflammation induced by dextran sodium sulfate (DSS) (Supplementary Fig

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8 The GlyNAC combination (glycine + NAC, addressing both rate-limiting precursors simultaneously) produced particularly robust results in a 16-week, placebo-controlled RCT in older adults: it corrected glutathione deficiency, reduced oxidative stress, improved mitochondrial fatty-acid oxidation, and enhanced physical performance measures including gait speed and the 6-minute walk test