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Switching from once-weekly to twice-weekly testosterone injections (splitting the total dose) can modestly reduce peak serum testosterone levels and may lower the risk of secondary polycythemia, as higher peaks are associated with greater hematocrit increases(El-Khatib et al., 2022
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tirzepatides 22.5% at 72 weeks), and no observed weight-loss plateau at the end of the study period participants were still losing weight when the trials ended, suggesting the full efficacy potential hadnt been reached
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