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Varying the grace period between 60 and 365 days meant that the discontinuation rates at 3 years after treatment initiation ranged from 23% to 44% among GLP-1 receptor agonist users and from 29% to 51% among SGLT2 inhibitor users

Erianin directly interacts with MEK1/2 and blocks the activation of MAPK signaling, thus effectively inhibiting the proliferation of pancreatic cancer cells and the characteristics of cancer stem cells, including suppression of sphere-forming capacity and the downregulation of key stemness markers, such as CD133, CD 44, sex determining region y-box 2 (SOX 2), and octamer-binding transcription factor 4 (OCT 4) (32)

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