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Studies have shown that N-terminal modifications of Incretins - specifically changing the second amino acid in the GLP-1 and GIP molecules from Ala to Gly or other amino acid can reduce the rate of DPP-4 inactivation of these peptides without impacting their ability to bind to their cognate receptors (Green and Flatt, 2007)
There is no blanket recommendation for or against taking probiotics while on GLP-1 medications, and the answer depends on the specific probiotic and your individual situation
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