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Unlike some vitamins, B12 is not produced by the human body and must be obtained from the diet or through supplementation

Garca-Gimnez, J

Specifically, antrocin regulates the cell cycle and apoptosis through the inhibition of -catenin mediated by IGF-1R, suggesting the potential value of antrocin as a potent therapeutic agent to overcome radioresistance (149)

Comparison with the binding modes of other dual and triple agonists highlight that the N-terminal and C-terminal regions of the peptide confer receptor selectivity, whereas the middle region offers opportunities for sequence optimization to refine receptor engagement, thereby presenting a useful template for designing better unimolecular therapeutics