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Semaglutide is a GLP-1 receptor agonist, which means it mimics the hormone GLP-1, which helps us feel fuller for longer after weve eaten

Even if GLP-1 levels themselves do not rise substantially, the bodys inflammatory or autonomic response may activate GLP-1like pathways, especially along the gut-brain axis

This means that while some people may notice effects like a mild increase in heart rate or heart palpitations, the medication can still provide long-term heart health benefits when used appropriately

Tricyclic antidepressants (TCAs) such as amitriptyline are associated with weight gain and potential insulin resistance, which may counteract the glucose-lowering effects of Ozempic