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The paraffin-embedded colon samples were sliced into 7 m sections using a microtome (RM2145, Leica Microsystems K.K, Tokyo, Japan) and then mounted on glass slides (Matsunami-glass, Osaka, Japan)
But are there increased risks associated with combining these higher doses
Studies show that on GLP-1 medications without proper protein intake and resistance exercise, up to 40% of total weight lost can come from muscle, not fat
In a study by Trahair et al., a GLP-1 agonist administered intravenously was shown to reduce the normal increase in superior mesenteric artery (SMA) blood flow in response to oral glucose [23]
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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