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4.4 Mechanistic exploration of repurposed anti-diabetic drugs Preclinical data reporting the neuroprotective effects of drugs such as GLP-1 receptor agonists (e.g., Liraglutide) and SGLT2 inhibitors raise the possibility that their benefits extend beyond glycemic control to potentially encompass the inhibition of ferroptosis (Ma et al., 2025)

The neurohormonal systems that semaglutide suppresses (hunger hormones, appetite signaling, metabolic adaptation) reactivate when the drug is withdrawn

Adding the second compound too early often leads to intense nausea and a forced step-down on one or both compounds

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